Listeria monocytogenes is a gram-positive, rod-shaped bacterium. It can be found in the environment as a soil inhabitant. However, it also can be a frequent contaminant of our food supply. As the latter, the bacterium is a significant public health concern, as it is capable of causing serious infections. Listeriosis (infection with Listeria) causes ~2500 serious illnesses and 500 deaths each year in the United States, and the hardest-hit are those with poor immune systems due to age (the very young and old), other immunocompromsing conditions (such as chemotherapy, organ transplant, or AIDS), and pregnant women. Once ingested, the bacterium is able to cross the intestine and spread throughout the body via the bloodstream, where it can attack organs and cause serious damage.
The very fact that it’s typically an environmental organism (rather than a solely pathogenic agent) likely accounts for some of its virulence and transmission. It’s able to survive a number of environmental stresses, including low temperature and high salt concentrations. Indeed, its ability to grow at relatively low temperatures is one way it evades our efforts to control it: it can grow in food even at refrigeration temperatures.
Listeria is particularly insidious as a cause of fetal death or other complications during pregnancy. Intrauterine infection can lead to preterm labor, spontaneous abortion, stillbirth, or serious–and potentially deadly–infection of the neonate. However, fairly little is known regarding exactly how this condition develops, or the mechanisms that lead to infection of the fetus. It has been thought that the increased susceptibility to infection with Listeria during pregnancy is largely due to a decrease in cell-mediated immunity that occurs as a result of pregnancy. This is a particularly attractive hypothesis for Listeria, which is an intracellular pathogen. A new paper in PLoS Pathogens examines this phenomenon in greater detail, using a guinea pig model of infection.
Continue reading “The evolutionary advantage of spontaneous abortion”
Even a microbiologist can’t keep her kids well 100% of the time. Have a post scheduled for later today but that’ll be it; hopefully things will be back to normal tomorrow. In the meantime, check out the newest edition of Pediatric Grand Rounds.
More interesting stories that I didn’t get to this week…
Continue reading “Saturday roundup”
I was new to Iowa last summer, and not being much of a bicycle person, had never heard of RAGBRAI, the [Des Moines] Register’s Annual Great Bicycle
Race Ride Across Iowa. (Don’t ask me why they didn’t pick a catchier acronym). It’s apparently a rather well-known ride, crossing Iowa from west to east on different routes each year. This year, it’s heading through my neck of the woods, and bringing with it a big name and a public health message:
Continue reading “Celebs flock to Iowa”
Check out the latest edition of Animalcules, the carnival of microbes, over at Science Matters. Additionally, for your macro organism fix, check out today’s Friday ark.
Here in the U.S., we’ve not found any high pathogenicity H5N1 influenza viruses, be it in our wild waterfowl, our domestic poultry, or our human population. But a recent story shows how quickly (and quietly) it could enter our country:
Continue reading “Coming soon to a store near you?”
I mentioned in this post on Ebola that I thought the authors were doing a bit too much extrapolation regarding their statement that the evolution of sociality in hominids has been constrained by pathogens such as Ebola. I didn’t elaborate on that topic because it’s a bit too far afield from my areas of expertise, but John Hawks has much more on the topic of pathogens and fitness in primate groups.
Received this press release in my email: Rudd Center Creates Blog for Discussion, Debate of Obesity Epidemic”
The Rudd Center for Food Policy & Obesity at Yale goes live today with a blog that encourages people to discuss topics ranging from how advertising determines what children eat to what pressures a bride-to-be is facing to squeeze into a size-four gown.
Continue reading “Yale obesity center starts new blog”